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Abstract

RNA Transcription and splicing errors as a source of cancer Frameshift Neoantigens for the Vaccines

The success of checkpoint inhibitors in cancer therapy is largely attributed to activating the patient’s immune response to their tumor’s neoantigens arising from DNA mutations. This realization has motivated the interest in personal cancer vaccines based on sequencing the patient’s tumor DNA to discover neoantigens. Here we propose an additional, unrecognized source of tumor neoantigens. We show that errors in transcription of microsatellites(MS) and mis-splicing of exons create highly immunogenic frameshift(FS) neoantigens in tumors. The sequence of these FS neoantigens are predictable, allowing creation of a peptide array


Author(s):

Fatemeh Babaiee



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